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Results and diagnoses were centrally adjudicated after patient discharge or death. The study excluded patients known to be infected with pseudomonas species or methicillin-resistant Staphylococcus aureus (MRSA), allergic to common antibiotic drugs, recent recipients of the study drugs, or expected to die or have a prolonged intensive care unit stay. Antibiotics were discontinued for negative cultures except at the physician's discretion among patients with a high pretest likelihood of ventilator-associated pneumonia.
Diagnostic ventilation cenon plus#
After these tests, patients were randomized to initial antibiotic treatment with the 1 g of Merrem (meropenem) every eight hours plus 400 mg of Cipro (ciprofloxacin) every 12 hours or Merrem alone.Īfter culture results were reported, the treating physicians were to use a single antibiotic with the narrowest spectrum targeted to the bacteria found in order to discontinue or reduce the dose or number of antibiotics. They randomized immunocompetent patients with suspected ventilator-associated pneumonia after at least four days in the ICU to undergo bronchoalveolar lavage with quantitative culture of the fluid recovered or endotracheal aspiration with nonquantitative culture of the aspirate.
Diagnostic ventilation cenon trial#
So the researchers used a larger trial comparing initial antimicrobial strategies to attempt to answer the question in a select group of patients.
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Many clinicians see bronchoalveolar lavage as more accurate, which would give them the confidence to stop unnecessary antibiotics or use narrow spectrum, targeted antibiotics that may help reduce antibiotic resistance, said Marin H. 21 issue of the New England Journal of Medicine. 20 - For critically ill patients on mechanical ventilation, bronchoalveolar lavage and endotracheal aspiration appear to be equally effective when diagnosing pneumonia, said researchers here.Īmong 740 patients in 28 North American intensive care units, there was no difference in clinical outcomes or antibiotic use associated with the diagnostic methods, reported Daren Heyland, M.D., of Kingston General Hospital and Queens University here, and colleagues in the Dec.